Skn-1a (Pou2f3) specifies taste receptor cell lineage

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Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice

Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami, and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the nasal respiratory epithelium, and tuft cells in the small intestine, that express taste-related genes function as chemosensory cells. Previous studies demonstrated that Skn-1a/Pou2f3, a POU homeodomain transcription fa...

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ژورنال

عنوان ژورنال: Nature Neuroscience

سال: 2011

ISSN: 1097-6256,1546-1726

DOI: 10.1038/nn.2820